ATM activation by transcription-induced DSBs
نویسندگان
چکیده
Drugs. The Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, NCI, National Institutes of Health (NIH), provided camptothecin (CPT) and flavopiridol (FLV). Aphidicolin (APD), 5,6-dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), and α-amanitin were obtained from Sigma (St Louis, MO). Hydrogen peroxide (H2O2) was obtained from Fisher Scientific (Pittsburgh, PA). Iodouridine (IdU) was obtained from Sigma. The ATM kinase inhibitor (KU55933) (Hickson et al, 2004) and the DNA-PK kinase inhibitor (KU57788) (Leahy et al, 2004) were obtained from Kudos Pharmaceuticals (Cambridge, UK).
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